![]() Out of the docked ligands, Ertapenem ( 2396) showed an ideal binding mode like that of the co-crystallized ligand ( SAM). Therefore, the 26 compounds were docked against 2′OMTase to reveal the potential inhibitory effect of seven promising compounds (Protirelin, ( 1187), Calcium folinate ( 1913), Raltegravir ( 1995), Regadenoson ( 2176), Ertapenem ( 2396), Methylergometrine ( 2532), and Thiamine pyrophosphate hydrochloride ( 2612)). Then, a structural similarity experiment recommended 26 compounds. At the beginning, molecular fingerprints experiment with SAM ( S-Adenosylmethionine), the co-crystallized ligand of the targeted enzyme, unveiled the resemblance of 147 drugs. ![]() The in silico inhibitory potential of the examined compounds against SARS-CoV-2 nsp16-nsp10 2′- o-methyltransferase (PDB ID: (6W4H) was conducted through a multi-step screening approach. ![]() As a continuation of our earlier work against SARS-CoV-2, seven FDA-approved drugs were designated as the best SARS-CoV-2 nsp16-nsp10 2′- o-methyltransferase (2′OMTase) inhibitors through 3009 compounds. ![]()
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![]() ![]() ![]() The movie which inevitably followed is crisper and more dramatic than its source (the novel, for example tells us about Brig's homosexual affair as soon as his character is described, whereas in the film it becomes a bombshell) and has Charles Laughton to provide a degree of menace and eccentricity in the character of the southern senator, Seabright Cooley, qualities which are less evident in the book because of Drury's insistence on providing a rational, indeed principled, motivation for even his more reprehensible characters. ![]() `It just gets a little mixed up sometimes.' "Īdvise and Consent won the Pulitzer Prize and sold more than a million copies. ![]() Drury's primary achievement is to reflect the strange combination of idealism and patriotism on the one hand, and cynicism and knavery on the other, which can still be found in the politics of the United States (and of everywhere else, come to that), though it is slightly unnerving to find this paradoxical juxtaposition being handled without irony: " `It is a wonderful country,' the director of the Post said. The many characters (there's a cast list at the beginning of the novel) simply represent points of view, which are elaborated in pages of rather heavy-handed dialogue, interrupted by lyrical evocations of Washington in various weather conditions, and substantial essays on the background of the principal players. Despite the complications of the protagonists' personal lives, and the deviousness of their political stratagems, there is no psychological complexity in the book. ![]() ![]() ![]() But the stories of its characters did not end there. The three Star Wars films form a spectacular saga of bold imagination and high adventure. ![]() Today Star Wars and its sequels, The Empire Strikes Back and Return of the Jedi, are acknowledged as the most popular series in movie history, and rank among the top ten films of all time. Its epic story, about a young man named Luke Skywalker, whose destiny was to save the galaxy from conquest, caught the imaginations of millions and broke all box-office records. In spring 1977 a film called Star Wars was released-and a cultural phenomenon was born. Picking up where the movie trilogy left off, Heir to the Empire reveals the tumultuous events that take place after the most popular series in motion-picture history-masterfully told by Hugo Award–winning author Timothy Zahn. Here is the science fiction publishing event of the year: the exciting continuation of the legendary Star Wars saga. ![]() ![]() ![]() ?Warning this post may contain spoilers ?Īs a queer person who loves to read i have been begging for more LGBT books that don’t just focus on the struggles of being gay and the lack of an understanding as a society. Only one thing feels certain: all that’s left in their world is the undeniable pull they have toward each other. The road ahead of them is long, and to survive, they’ll have to shed their secrets, face the consequences of their actions, and find the courage to fight for the future they desire, together. He’s starting to feel something more than friendship for Andrew, adding another layer of fear and confusion to an already tumultuous journey. But something isn’t adding up about Andrew’s story, and it could cost them everything. ![]() so why does it seem so easy for them to trust each other?Īfter danger breaches their shelter, they flee south in search of civilization. And if this new world has taught them anything, it’s to be scared of what other desperate people will do. ![]() A deadly pathogen has killed off most of the world’s population, including everyone both boys have ever loved. When Andrew stumbles upon Jamie’s house, he’s injured, starved, and has nothing left to lose. Perfect for fans of Adam Silvera, Alex London, and Heartstopper by Alice Oseman. What If It's Us meets They Both Die at the End in this postapocalyptic, queer YA adventure romance from debut author Erik J. ![]() ![]() ![]() ![]() The two girls are matching except for the buttons on their dresses. There is a feeling that this is entirely imaginary yet that it may also be delightfully real.ĭoi’s illustrations are a large part of the appeal of this book. Instead it has an exceptional childlike nature that fills it with wonder and the joy of exploration. The description may seem a bit too sweet and almost saccharine, but the book is not like that. ![]() The picture book is delightful and airy, inviting children into a world built just for them. This is a translation from the Japanese original, and it works very well. The day ends with the girls joining in a forest concert as everyone sings together. They bicycle farther on and as the sun is setting come to a forest hotel where they find a room and beds just the right size for them. They play in the water, nap under a tree. The girls choose their sandwiches and eat them near a pond. Then they are off again into the forest and they find a bakery with bread and jam of all kinds. They order cups of acorn coffee and clover blossom tea. They arrive at the forest cafe where there are tables just right for creatures and people of any size. Chirri and Chirra are two little girls who wake up early and head out into the forest together on their bicycles. ![]() ![]() ![]() Newly orphaned, he considers what it means, in his seventh decade, no longer to be someone’s son. His offer to fix a stranger’s teeth rebuffed, he straightens his own, and ventures into the world with new confidence. ![]() ![]() He vacuums his apartment twice a day, fails to hoard anything, and contemplates how sex workers and acupuncturists might be getting by during quarantine.Īs the world gradually settles into a new reality, Sedaris too finds himself changed. To cope, he walks for miles through a nearly deserted city, smelling only his own breath. As Happy-Go-Lucky opens, he is learning to shoot guns with his sister, visiting muddy flea markets in Serbia, buying gummy worms to feed to ants, and telling his nonagenarian father wheelchair jokes.īut then the pandemic hits, and like so many others, he’s stuck in lockdown, unable to tour and read for audiences, the part of his work he loves most. ![]() David Sedaris, the “champion storyteller,” ( Los Angeles Times ) returns with his first new collection of personal essays since the bestselling Calypso Back when restaurant menus were still printed on paper, and wearing a mask-or not-was a decision made mostly on Halloween, David Sedaris spent his time doing normal things. ![]() ![]() ![]() However, Barrie’s fictional creation is not entirely original and is in fact based on the mythological Greek God, Pan. From its first performance as a play in 1904 to its transition into a novel in 1911, to contemporary 21st century, the titular character has continued to be a significant fictional figure and has been the subject of much critical analysis. J.M Barrie’s classical character Peter Pan, for instance has undoubtedly become a part of popular culture. In this article, I will look closely at the Pan figure that appears to have a presence in numerous Children’s Novels. ![]() Whilst taking a module focused on Children’s Literature, I became increasingly passionate concerning texts aimed at children. ![]() (Note: This posts may be a little on the lengthy side). So if you find this article informative of useful in anyway, or just have some general feedback, let me know in the comments below. Now that I have little more free time, I hope to continue to write posts/articles such as this. So, today I thought I would upload a different kind of post, now that I’ve finished university, I oddly miss analysing texts and writing detailed and informative essays of them. ![]() ![]() The series brings the story of the Black Church through Emancipation and Reconstruction, through the Civil Rights era up to the present - a time of renewed struggle for racial justice in America.Īlong with our own Presiding Bishop Charles E. explores the roots of African American religion, beginning with the trans-Atlantic slave trade and the extraordinary ways enslaved Africans preserved and adapted their faith practices under the brutal realities of human bondage. The documentary reveals how Black people have worshiped and, through their spiritual journeys, improvised ways to bring their faith traditions from Africa to the New World, while translating them into a form of Christianity that was not only truly their own, but a redemptive force for a nation whose original sin was found in their ancestors’ enslavement across the Middle Passage. It is a testament to its bedrock role as the site of African American survival and grace, organizing and resilience, thriving and testifying, autonomy and freedom, solidarity, and speaking truth to power. ![]() The program explores the 400-year-old story of the Black church in America, the changing nature of worship spaces, and the men and women who shepherded them from the pulpit, the choir loft, and church pews. ![]() ![]() The Black Church: This Is Our Story, This Is Our Song is a moving four-hour, two-part series from executive producer, host, and writer Henry Louis Gates, Jr., Professor at Harvard University and director of the Hutchins Center for African and African American Research. ![]() ![]() ![]() Un intenso lavoro di traduzione e ricerca bibliografica lo porta così alla ricostruzione dell’intricata e travolgente vicenda. ![]() Il prologo permette di entrare nel cuore della storia, costruita su un espediente letterario: l’autore racconta di aver letto durante un soggiorno all’estero il manoscritto di un monaco benedettino relativo a una misteriosa vicenda svoltasi in età medievale in un’abbazia dell’Italia settentrionale. Ristampato innumerevoli volte, tradotto in più di quaranta lingue, con oltre cinquanta milioni di copie vendute: i numeri del romanzo confermano un fenomeno editoriale come pochi. Il primo capolavoro di Eco vinse anche il Premio Strega nel 1981. Un successo senza eguali, per la critica e il pubblico adattato per la radio, il teatro, il cinema e la TV (la fiction, diretta da Giacomo Battiato e andata in onda su Rai Uno nel 2018, è stata un successo di audience). ![]() Il nome della rosa di Umberto Eco resta uno dei capisaldi della letteratura italiana, inserito tra i “100 libri del secolo” dal francese Le Monde. Un romanzo senza tempo, edito per la prima volta da Bompiani nel 1980. ![]() ![]() ![]() A gripping saga that chronicles the destiny of Nora and Patch from the beginning of their relationship to the dire events–and forces–that threaten to tear them apart, this collection of all four Hush, Hush books is the perfect paranormal present for loyal fans and series newcomers. ![]() Enter the realm of fallen angels and rising passions with this boxed set that includes Hush, Hush, Crescendo, Silence, and Finale. You can read this before The Complete Hush, Hush Saga: Hush, Hush Crescendo Silence Finale (Hush, Hush #1-4) PDF EPUB full Download at the bottom.Īll four books in the New York Times bestselling Hush, Hush saga are now available in a collectible hardcover boxed set. ![]() Here is a quick description and cover image of book The Complete Hush, Hush Saga: Hush, Hush Crescendo Silence Finale (Hush, Hush #1-4) written by Becca Fitzpatrick which was published in. Brief Summary of Book: The Complete Hush, Hush Saga: Hush, Hush Crescendo Silence Finale (Hush, Hush #1-4) by Becca Fitzpatrick ![]() |